Abstract: An isocratic HPLC method has been developed for determination of ambroxol, salbutamol, and fexofenadine in their pure and tablet forms. Separation was carried out at room temperature on an Equisil BDS C18 (5 um, 4.60 mm x 150 mm) column using a mobile phase of acetonitrile and...
Keywords: HPLC; Ambroxol; Salbutamol; Fexofenadine
Special Issue Article “Nonsteroidal Anti-Inflammatory Drug”
Abstract: We previously isolated oxo-cyclohexene-acetic acid,ketomycin, from a culture filtrate of Actinomycetes as an inhibitor of cancer cell migration and invasion. The mechanistic study revealed that it inhibited constitutively activated NF-kB and downstream MMP-9 and 11 expressions in human...
Keywords: Ketomycin; NF-B; I-B kinase; Surface plasmon resonance; Interleukin-6; Macrophage
Special Issue Article “Substance Use and Abuse in Adolescents”
Abstract: This commentary draws on my multiple decades experience working on adolescent drug use issues, particularly involving youth in the justice system. Reflections are made on key issues in the field, progress made, and challenges that need to be overcome in moving the field forward.....
Keywords: Adolescents drug use justice involved youth
Special Issue Article “Generic Drug”
Abstract: Development of medications, by research based pharmaceutical companies, costs of the order of > 2.5 billion US dollars, especially when amortised over the costs involved with other failed attempts to develop innovative compounds of which > 90% fail at the animal testing...
Keywords: Generic Substitution; Bioequivalence; Trade names; Variation
Special Issue Article “Cyclophosphamide”
Abstract: There are two treatment options for interstitial lung disease-associated with systemic sclerosis (SSc-ILD), namely, immunosuppressants (cyclophosphamide, mycophenolate mofetil, etc.) and anti-fibrotic drug (nintedanib). The efficacy of immunosuppressants for SSc-ILD is variable...
Keywords: Systemic sclerosis Digital ulcer Digital shortening Atrophy of finger pad Cyclophosphamide Interstitial lung disease
Special Issue Article “Generic Drugs”
Abstract: The increasing use of lower-cost multiple sourced medicines (generics) and biosimilars are essential to attain or retain universal healthcare in the face of continual pressure on available resources. Alongside this, reduce patient co-payments and enhance access to medicines in countries...
Keywords: Generic drug; Venlafaxine; Angiotensin
Abstract: Oxcarbazepine has various actions. It can be used for treatment of epilepsy, trigeminal neuralgia, and diabetic neuropathy. In the animal study, oxcarbazepine has some evidence that it could be used for treatment of inflammatory pain and morphine tolerance....
Keywords: Oxcarbazepine; Carbamazepine; Schizophrenia
Abstract: Celecoxib is a selective COX-II inhibitor drug that is used as an anti-inflammatory, analgesic, and antipyretic drug. In this literature review, we will shed the light on its pharmacological action beside most of up-to-date reported methods that have been developed for its determination in its pure form...
Keywords: Literature review; Celecoxib; Anti-inflammatory; Degradation products; Biological samples
Special Issue Article “Drug Overdose”
Abstract: A preterm infant, born at 27.2 weeks of gestation and treated for persistent patent ductus arteriosus, received inadvertently a total dose of 780 mg/kg Acetaminophen (APAP) intravenously in 13 divided doses over 3 days, instead of 60 mg/kg/day as recommended...
Keywords: Acetaminophen; APAP; Paracetamol Overdose; Hepatotoxicity preterm; Drug metabolism
Abstract: In this literature review, we will introduce mode of action and most of up-to-date reported methods that have been developed for determination of certain oral hypoglycemic drugs, such as metformin hydrochloride, glibenclamide, glimepiride and pioglitazone hydrochloride in their pure form...
Keywords: Review; Hypoglycemic; Metformin; Glibenclamide; Glimepiride; Pioglitazone
Special Issue Article “Paracetamol”
Abstract: Paracetamol (acetaminophen) is an over-the-counter analgesic, antipyretic and anti-inflammatory drug. There are numerous generics of Paracetamol tablets, both locally produced and imported brands are available within the health care delivery system in Ghana....
Keywords: Paracetamol; Acetaminophen uniformity; Disintegration dissolution; Assay; In-Vitro; Quality; Evaluation; Ghana
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